Chosen Speaker of the South Carolina House of Representatives in 1789, Read repeatedly offered himself for higher office without success. Finally, in 1794, he won election to the U.S. Senate, where he sat from 1795 to 1801. A Federalist with close ties to the mercantile community, Read cast the crucial vote necessary for ratification of the Jay Treaty, for which a Charleston mob opposing the accord hung him in effigy and threatened his home.