McKissick led the university through the tumultuous times of the Great Depression and World War II. With help through the New Deal, McKissick presided over the construction of a new library and five dormitories, as well as a general refurbishment of the campus. During World War II, McKissick guided the university into the war effort, establishing civilian pilot and laboratory technician training programs, adjusting the curriculum to include defense-oriented science and engineering courses, and establishing the nation’s first Red Cross nurse’s aide course.